“Is there a certain size you're looking for?”
You work at a clothing store. You see a customer who's looking at pants but seems to want something specific. You ask him this to offer your help.
Is there a certain size you're looking for?
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Is there (something)(clause)?
Here are some examples of "Is there ___?":
Is there a day when we could meet and discuss this in depth?
Is there anyone I can talk to about the status of my application?
Is there something you wanted to tell me?
Use this kind of sentence when you want to ask about whether a certain kind of thing exists.
Use "Is there ___?" in situations where you need to be polite. When you ask a simple question like:
What size are you looking for?
...the question assumes that the listener is looking for a size. But maybe he isn't. Maybe he's looking for a certain style instead of a certain size. So it's more polite to ask:
Is there a certain size you're looking for?
a certain (thing)
The word "a" can mean different things. It can mean something specific or something general. For example, the phrase "a movie" can be used specifically:
I saw a movie last night.
Or it can mean something general:
It's fun to go out to see a movie every once in a while.
But when you use the phrase "a certain ___", it's clear that you mean a specific thing.
I made the mistake of telling a certain friend about my problems with Jeff, and next thing you know the whole school was talking about it.
Let's just choose a certain day to meet for a few hours each week.
look for (something)
The phrase "look for" usually needs to have something after it:
I'm looking for a gift for my husband.
But in questions, that part comes earlier:
What are you looking for?
There's an old rule that some English teachers might try to enforce, which says that you shouldn't end a sentence with a preposition like "for". According to this rule, you're supposed to say or write:
For what are you looking?
But this is really strange and old-fashioned. You can use it in extremely formal writing, or maybe as a joke.